Show me:
Show me:
heartfoundation.org.au|Helpline 13 11 12

Understanding the gene environment interaction in diabetes associated atherosclerosis

Dr Abdul Waheed Khan, Institution: Monash University

2019 Postdoctoral Fellowship

Years funded: 2020-2022 


Diabetes can damage blood vessels by accelerating the process of fatty plaque development known as atherosclerosis. The prevalence of atherosclerosis is increasing rapidly worldwide. Atherosclerosis begins with endothelial cells damage ultimately leading to blood vessel blockage. Endothelial cells line the interior surface of blood vessels and are the first type of cells exposed to high blood glucose levels. Endothelial damage in the blood vessels is evident in patients with diabetes.There is no effective treatment to date that would address endothelial injury in diabetes. EZH2 is an enzyme that changes chromatin structure to regulate the expression of genes involved in endothelial damage. Several studies have found that EZH2 activity is elevated in high glucose treated endothelial cells. However, whether this over activity of EZH2 damages endothelial cells in diabetes-associated atherosclerosis is not known. Thus, I hypothesize that over-activity of EZH2 mediated by high glucose concentrations and other stressors such as high fat diet is associated with endothelial damage and atherosclerosis. I will address this using pharmacological and genetic approaches in animal model of diabetic atherosclerosis. In the pharmacological approach, I will use a drug that inhibits EZH2 activity and thus may improve endothelial function and protect vessels from plaque development. In the genetic approach, I will generate endothelial specific knockout mice and use streptozotocin to make them diabetic. Aorta and blood will be collected at the end of study for functional, structural and molecular analysis. By directly testing the efficacy of pharmacological inhibition of EZH2, our results may provide evidence for the potential use of chromatin modifying drug in preventing vascular damage caused by high blood glucose concentrations.

You might also be interested in

Research Directory

Research Directory

A program of research to improve ACCESS to cardiovascular care

A program of research to improve ACCESS to cardiovascular care

Professor Robyn Clark, Institution: Flinders University...

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Assistant Professor Neil Spratt, Institution: The University of Newcastle...

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Ms Joanne Luke, Institution: University of Melbourne...

Exercise and brain volume loss after stroke

Exercise and brain volume loss after stroke

Professor Amy Brodtmann, Institution: Florey Institute of Neuroscience and Mental Health...

Growing healthy hearts - how passive smoke exposure and elevated blood pressure early in life impacts adult cardiovascular health

Growing healthy hearts - how passive smoke exposure and elevated blood pressure early in life impacts adult cardiovascular health

Growing healthy hearts - how passive smoke exposure and elevated blood pressure early in life impacts adult cardiovascular health

Dr Costan Magnussen, Institution: University of Tasmania...

Lipid disorders in patients at high cardiovascular disease risk

Lipid disorders in patients at high cardiovascular disease risk

Dr Esther Ooi, Institution: University of Western Australia...

Promoting active, healthy lifestyles among women at key life stages

Promoting active, healthy lifestyles among women at key life stages

Associate Professor Verity Cleland, Institution: University of Tasmania...

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Professor Bruce Neal, Institution: University of New South Wales...

Starting early – Increasing young children’s physical activity

Starting early – Increasing young children’s physical activity

Associate Professor Hayley Christian, Institution: University of Western Australia...

Time to book a Heart Health Check?

Time to book a Heart Health Check?

Time to book a Heart Health Check?

If you're 45 and over, or 30 and over if you're of Aboriginal or Torres Strait Islander descent, you should book your Heart Health Check today...

Heart Health Check Toolkit

Heart Health Check Toolkit

Health Professional Tools

Health Professional Tools

Health Professional Tools

Guidelines, publications and support for the health professional community....

Together, we can change the future of heart disease

Together, we can change the future of heart disease

Together, we can change the future of heart disease

The power of your ongoing support can help save lives and keep more families together. Help us continue to fund promising heart research projects by donating today. ...

Understanding how kidney failure leads to heart disease

Understanding how kidney failure leads to heart disease

Associate Professor Natasha Rogers, Institution: University of Sydney...

Heart Foundation Walking

Heart Foundation Walking

Heart Foundation Walking

Learn more about Heart Foundation Walking and find your local walking group....

Cardiac rehabilitation resources for healthcare providers

Cardiac rehabilitation resources for healthcare providers

Useful cardiac rehabilitation resources for health professionals....

Improving heart health of Indigenous Australian families – ‘Healthy Dads, Healthy Kids – Indigenous’

Improving heart health of Indigenous Australian families – ‘Healthy Dads, Healthy Kids – Indigenous’

Improving heart health of Indigenous Australian families – ‘Healthy Dads, Healthy Kids – Indigenous’

Professor Philip Morgan, Institution: The University of Newcastle...

What is heart disease?

What is heart disease?

What is heart disease?

Heart disease is the broad term for conditions that affect the structure and function of the heart muscle. ...

Physical activity resources for patients and consumers

Physical activity resources for patients and consumers

Physical activity information for professionals...

For professionals: Guidelines for acute rheumatic fever and rheumatic heart disease

For professionals: Guidelines for acute rheumatic fever and rheumatic heart disease

Australian  guidelines  for  prevention, diagnosis and  management of  acute  rheumatic  fever and  rheumatic  heart  disease ...

Action Plans

Action Plans

Action Plans

Recovery is a long journey, so having a plan makes a huge difference. Using an action plan gives you a step-by-step guide to improving your lifestyle....

Easy chicken nasi goreng

Easy chicken nasi goreng

Easy chicken nasi goreng

10 minutes
Serves 4

Testing the feasibility of banning energy drink sales to children to protect their heart health

Testing the feasibility of banning energy drink sales to children to protect their heart health

Dr Gina Trapp, Institution: University of Western Australia...

Healthy eating to protect your heart

Healthy eating to protect your heart

Healthy eating to protect your heart

What does a heart-friendly diet look like?...

Using ultrasound therapy to improve blood flow and save heart muscle during heart attack

Using ultrasound therapy to improve blood flow and save heart muscle during heart attack

Using ultrasound therapy to improve blood flow and save heart muscle during heart attack

Dr Prajith Jeyaprakash, Institution: University of Sydney...

Finding a new purpose: Geoff Lester’s heart story

Finding a new purpose: Geoff Lester’s heart story

Finding a new purpose: Geoff Lester’s heart story

Dr Geoff Lester, 35, is training to be a cardiologist at Coffs Harbour Hospital. He has survived three high-risk open-heart surgeries and two strokes....

Q&A with Professor Levon Khachigian

Q&A with Professor Levon Khachigian

Q&A with Professor Levon Khachigian

Developing a new medicine for inflammatory cardiovascular disease...

Chicken and two-grain stuffed capsicums

Chicken and two-grain stuffed capsicums

Chicken and two-grain stuffed capsicums

10 - 12 minutes
Serves 4

End of Financial Year Tax Receipt

End of Financial Year Tax Receipt

End of Financial Year Tax Receipt

Looking to claim your donations in your tax return this financial year?...

Is salt bad for your heart?

Is salt bad for your heart?

Is salt bad for your heart?

Most Australians are eating more than the recommended amounts and this can cause health problems....

Heart failure resources for patients

Heart failure resources for patients

Educate your patients on everything they need to know about heart failure and managing their condition ...

My Heart, My Life program and support resources

My Heart, My Life program and support resources

My Heart, My Life program and support resources

Learn how the Heart Foundation can support you and your loved ones. ...

Lamb recipes

Lamb recipes

Lamb recipes

Find heart healthy lamb recipes....

Smoking and your heart

Smoking and your heart

Smoking and your heart

Understand how smoking can impact your heart health. ...

Absolute CVD risk assessment resources

Absolute CVD risk assessment resources

Resources and clinical information for health professionals...

Maryanne was shocked to find she had a hidden heart problem

Maryanne was shocked to find she had a hidden heart problem

Maryanne was shocked to find she had a hidden heart problem

At first, it didn’t cross my mind it could be something serious. ...

What is coronary heart disease?

What is coronary heart disease?

What is coronary heart disease?

Coronary heart disease (CHD) or coronary artery disease occurs when a coronary artery clogs and narrows because of a buildup of plaque....

Coronary Angiogram Test

Coronary Angiogram Test

This is a common test done to find out angina symptoms, or during or after a heart attack. ...

Dairy and your heart health

Dairy and your heart health

Dairy and your heart health

Not all dairy products are equal. Discover different types of dairy foods and their impact on heart health....