Show me:
Show me:
heartfoundation.org.au|Helpline 13 11 12

New Models of Care and Treatment Strategies in HFpEF

Dr John O'Sullivan, Institution: University of Sydney

2020 Future Leader Fellowship

Years funded: 2021-2024


Heart failure with a stiff heart but relatively preserved contraction (Heart Failure with preserved Ejection Fraction or ‘HFpEF’) has become the commonest type of heart failure in the community and hospital environment. Like the readily-recognised heart failure with reduced contraction (HFrEF), it has a poor outlook- typically patients survive about 2 years from diagnosis during which time they are chronically ill, have poor quality of life, and frequent admissions to hospital. Despite many scientifically-proven treatments for HFrEF, there are none for HFpEF. There is a pressing need to improve understanding of HFpEF, develop novel treatments, and implement these into clinical practice. Although patients with HFpEF collectively have similar heart abnormalities, we believe that there are several sub-classes corresponding to the most prevalent underlying conditions (high blood pressure, diabetes, sleep apnoea).

Therefore, we propose to:
  1. Understand the key mechanisms underlying contributors to this disease (e.g. high blood pressure, diabetes, low oxygen due to sleep apnoea).
  2. Improve characterisation of HFpEF subtypes using specialised tests such as cardiac MRI and sleep studies.
  3. Using these results, design tailored models-of-care for each subtype (precision medicine).
  4. Implement the tailored models-of-care and determine if they improve outcome.
  5. In parallel, test a new heart-specific drug we are developing using human heart cells and human HFpEF heart tissue.

You might also be interested in

Research Directory

Research Directory

A program of research to improve ACCESS to cardiovascular care

A program of research to improve ACCESS to cardiovascular care

Professor Robyn Clark, Institution: Flinders University...

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Assistant Professor Neil Spratt, Institution: The University of Newcastle...

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Ms Joanne Luke, Institution: University of Melbourne...

Exercise and brain volume loss after stroke

Exercise and brain volume loss after stroke

Professor Amy Brodtmann, Institution: Florey Institute of Neuroscience and Mental Health...

Growing healthy hearts - how passive smoke exposure and elevated blood pressure early in life impacts adult cardiovascular health

Growing healthy hearts - how passive smoke exposure and elevated blood pressure early in life impacts adult cardiovascular health

Growing healthy hearts - how passive smoke exposure and elevated blood pressure early in life impacts adult cardiovascular health

Dr Costan Magnussen, Institution: University of Tasmania...

Lipid disorders in patients at high cardiovascular disease risk

Lipid disorders in patients at high cardiovascular disease risk

Dr Esther Ooi, Institution: University of Western Australia...

Promoting active, healthy lifestyles among women at key life stages

Promoting active, healthy lifestyles among women at key life stages

Associate Professor Verity Cleland, Institution: University of Tasmania...

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Professor Bruce Neal, Institution: University of New South Wales...

Starting early – Increasing young children’s physical activity

Starting early – Increasing young children’s physical activity

Associate Professor Hayley Christian, Institution: University of Western Australia...

Time to book a Heart Health Check?

Time to book a Heart Health Check?

Time to book a Heart Health Check?

If you're 45 and over, or 30 and over if you're of Aboriginal or Torres Strait Islander descent, you should book your Heart Health Check today...

Together, we can change the future of heart disease

Together, we can change the future of heart disease

Together, we can change the future of heart disease

The power of your ongoing support can help save lives and keep more families together. Help us continue to fund promising heart research projects by donating today. ...

Health Professional Tools

Health Professional Tools

Health Professional Tools

Guidelines, publications and support for the health professional community....

Heart Health Check Toolkit

Heart Health Check Toolkit

WEBINAR | Heart Health Checks: the critical role of the practice nurse

WEBINAR | Heart Health Checks: the critical role of the practice nurse

WEBINAR | Heart Health Checks: the critical role of the practice nurse

This webinar discusses the role of practice nurses in conducting heart health checks...

Lamb recipes

Lamb recipes

Lamb recipes

Find heart healthy lamb recipes....

What is heart failure?

What is heart failure?

What is heart failure?

Heart failure is a condition where your heart isn’t pumping as well as it should be....

10 steps to protect your heart health

10 steps to protect your heart health

10 steps to protect your heart health

Ready to help your heart keep on beating? Here are 10 important ways to reduce your risk of heart disease for a healthier life.  ...

Italian veggie fritters with tomato salad

Italian veggie fritters with tomato salad

Italian veggie fritters with tomato salad

20 minutes
Serves 4 (as a main meal)

Action Plans

Action Plans

Action Plans

Recovery is a long journey, so having a plan makes a huge difference. Using an action plan gives you a step-by-step guide to improving your lifestyle....

What waist measurements mean for your heart

What waist measurements mean for your heart

What waist measurements mean for your heart

How your waist measurement contributes to your heart health...

How can I set and achieve goals to improve my heart health?

How can I set and achieve goals to improve my heart health?

How can I set and achieve goals to improve my heart health?

Question of the month blog...

Environment, climate change and heart health

Environment, climate change and heart health

Environment, climate change and heart health

Information on how air pollution, heatwaves and bushfires can impact heart health, and what you can do to look after yourself. ...

Is salt bad for your heart?

Is salt bad for your heart?

Is salt bad for your heart?

Most Australians are eating more than the recommended amounts and this can cause health problems....

Mediterranean antipasto pizza

Mediterranean antipasto pizza

Mediterranean antipasto pizza

10 minutes
Serves 4 (1 pizza per serve)

For professionals: Aboriginal and Torres Strait Islander peoples identification training

For professionals: Aboriginal and Torres Strait Islander peoples identification training

Asking the Question of Origin course helps with identification of Aboriginal and Torres Strait Islander patients, in line with standard practice.  ...

Heart stories

Heart stories

Heart stories

Stories of hope from Australian men and women fighting heart disease....

Q&A with Dr Jessica O’Brien

Q&A with Dr Jessica O’Brien

Q&A with Dr Jessica O’Brien

Quantifying myocardial inflammation in acute rheumatic fever and rheumatic heart disease...

Driving Best Practice CVD Prevention in a Post-COVID World

Driving Best Practice CVD Prevention in a Post-COVID World

Driving Best Practice CVD Prevention in a Post-COVID World

Coronary Artery Calcium Scoring

Coronary Artery Calcium Scoring

A coronary artery calcium score can be used following a Heart Health Check to estimate your risk of heart attack....

45 & Up Study

45 & Up Study

The 45 and Up Study is one of the largest ongoing cohort studies of healthy ageing in the world and the largest in Australia. ...

Harness mechanical force on platelets to combat deadly blood clotting

Harness mechanical force on platelets to combat deadly blood clotting

Dr Lining Arnold Ju, Institution: University of Sydney...

Raffles & Lotteries

Raffles & Lotteries

Raffles & Lotteries

Give yourself a chance to win up to $25,000* while helping the Heart Foundation to raise essential funds for heart research....

One pot green goodness pasta

One pot green goodness pasta

One pot green goodness pasta

15 minutes
Serves 2

Chicken cacciatore

Chicken cacciatore

Chicken cacciatore

15 minutes
Serves 4

Q&A with Dr Nathan Palpant

Q&A with Dr Nathan Palpant

Q&A with Dr Nathan Palpant

Deadly spider venom offers hope to people having a heart attack...

Are immune cells responsible for heart attacks and strokes?

Are immune cells responsible for heart attacks and strokes?

Professor Karlheinz Peter, Institution: The University of Melbourne...

For professionals: Heart failure tools and resources

For professionals: Heart failure tools and resources

Resources for healthcare professionals on the management of patients with heart failure ...

Paprika chicken with pumpkin and spinach salad

Paprika chicken with pumpkin and spinach salad

32 minutes
Serves 4

Using ultrasound therapy to improve blood flow and save heart muscle during heart attack

Using ultrasound therapy to improve blood flow and save heart muscle during heart attack

Using ultrasound therapy to improve blood flow and save heart muscle during heart attack

Dr Prajith Jeyaprakash, Institution: University of Sydney...