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Lipid disorders in patients at high cardiovascular disease risk

Dr Esther Ooi, Institution: University of Western Australia

2014 Future Leader Fellowship

Years funded: 2015-2020


Emerging evidence suggests that people with high blood levels of a molecule known as lipoprotein(a) – or Lp(a) – have a 60% higher risk of dying from a heart attack.

Lp(a) is a low density lipoprotein (LDL), or bad cholesterol-like molecule found in the blood. Why Lp(a) levels are high, how Lp(a) may be lowered, and the prevalence of high Lp(a) in Australian communities have not been established.

This project will study how Lp(a) is processed by the liver and the body. It will explore how new medical treatments lower Lp(a) levels; and lastly it aims to identify the prevalence of high Lp(a) in people with premature heart disease.

This research will offer new information about the formation and breakdown of Lp(a). It will be useful to doctors looking to find ways to treat high Lp(a) disorders. It may also inform the development of new therapies that in the future may be used to treat people and their families with high Lp(a).

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