Show me:
Show me:
heartfoundation.org.au|Helpline 13 11 12

Assessment of the efficacy of a novel treatment for blocked leg arteries

Professor Jonathan Golledge, Institution: James Cook University

2018 Vanguard Grant

Years funded: 2019-2021


Blockage of the lower limb arteries (peripheral artery disease; PAD) leads to severe leg pain, walking impairment, and a substantial risk of leg amputation and death. Approximately 200 million people worldwide and approximately 1 million Australians have blocked leg arteries. This problem has recognised treatment deficiencies in comparison to other common diseases, including the absence of effective medications to increase blood supply to the legs, reduce leg pain, improve walking ability and reduce the risk of major amputation.

Multiple lines of evidence suggest that metformin, a cheap and safe medication, promotes formation of new vessels, improves microcirculation and muscle function and limits pain. In preliminary studies, metformin significantly increased blood supply to the limb in a pre-clinical model of blocked leg arteries. We have also associated metformin prescription with a 4-fold reduction in the rate of major lower limb amputation in patients with blocked arteries.

 This placebo-controlled, randomised clinical trial will examine the efficacy of metformin in improving walking ability over 30 weeks in patients with blocked leg arteries. Positive findings from this trial will identify a new treatment for a problem that affects approximately 10% of adults aged over 50 years.

You might also be interested in

Research Directory

Research Directory

A program of research to improve ACCESS to cardiovascular care

A program of research to improve ACCESS to cardiovascular care

Professor Robyn Clark, Institution: Flinders University...

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Assistant Professor Neil Spratt, Institution: The University of Newcastle...

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Ms Joanne Luke, Institution: University of Melbourne...

Exercise and brain volume loss after stroke

Exercise and brain volume loss after stroke

Professor Amy Brodtmann, Institution: Florey Institute of Neuroscience and Mental Health...

Growing healthy hearts - how passive smoke exposure and elevated blood pressure early in life impacts adult cardiovascular health

Growing healthy hearts - how passive smoke exposure and elevated blood pressure early in life impacts adult cardiovascular health

Growing healthy hearts - how passive smoke exposure and elevated blood pressure early in life impacts adult cardiovascular health

Dr Costan Magnussen, Institution: University of Tasmania...

Lipid disorders in patients at high cardiovascular disease risk

Lipid disorders in patients at high cardiovascular disease risk

Dr Esther Ooi, Institution: University of Western Australia...

Promoting active, healthy lifestyles among women at key life stages

Promoting active, healthy lifestyles among women at key life stages

Associate Professor Verity Cleland, Institution: University of Tasmania...

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Professor Bruce Neal, Institution: University of New South Wales...

Starting early – Increasing young children’s physical activity

Starting early – Increasing young children’s physical activity

Associate Professor Hayley Christian, Institution: University of Western Australia...

Heart Health Check Toolkit

Heart Health Check Toolkit

Time to book a Heart Health Check?

Time to book a Heart Health Check?

Time to book a Heart Health Check?

If you're 45 and over, or 30 and over if you're of Aboriginal or Torres Strait Islander descent, you should book your Heart Health Check today...

Together, we can change the future of heart disease

Together, we can change the future of heart disease

Together, we can change the future of heart disease

The power of your ongoing support can help save lives and keep more families together. Help us continue to fund promising heart research projects by donating today. ...

Health Professional Tools

Health Professional Tools

Health Professional Tools

Guidelines, publications and support for the health professional community....

Support for young adults: Online events

Support for young adults: Online events

Support for young adults: Online events

Check back in for the latest updates on Supporting Young Heart events...

Chicken chimichurri

Chicken chimichurri

Chicken chimichurri

15 minutes
Serves 4

Nutrition after a heart attack

Nutrition after a heart attack

Nutrition after a heart attack

Discover key information on heart-healthy eating and drinking....

Loaded veggie shepherds pie

Loaded veggie shepherds pie

Loaded veggie shepherds pie

1 hour
Serves Serves 4 (as a main meal)

Aussie men among the world’s most obese, new data

Aussie men among the world’s most obese, new data

Aussie men among the world’s most obese, new data

Media Release - 16 November 2020...

Cardiac arrests in young people — what causes them, can they be prevented or treated?

Cardiac arrests in young people — what causes them, can they be prevented or treated?

Cardiac arrests in young people — what causes them, can they be prevented or treated?

Cardiomyopathy; another health curveball for Ange

Cardiomyopathy; another health curveball for Ange

Cardiomyopathy; another health curveball for Ange

A story from Ange Foster ...

Dinner recipes

Dinner recipes

Dinner recipes

Search our heart healthy dinner recipes for tonights main meal...

Sodium Glucose Co-transporter 2 Inhibitors as a Novel Treatment for Atrial Fibrillation

Sodium Glucose Co-transporter 2 Inhibitors as a Novel Treatment for Atrial Fibrillation

Dr Kathryn Tiver, Institution: Flinders University...

Clinical Guidelines

Clinical Guidelines

Clinical Guidelines

Full list of clinical guidlines and references for CVD, heart failure, ACS, hypertension, atrial fibrillation, SCAD and RHD...

Intervening in early childhood to improve physical activity and heart health throughout life

Intervening in early childhood to improve physical activity and heart health throughout life

Intervening in early childhood to improve physical activity and heart health throughout life

Professor Kylie Hesketh, Institution: Deakin University...

Beef recipes

Beef recipes

Beef recipes

Find heart healthy beef recipes....

Postdoctoral Fellowship

Postdoctoral Fellowship

This fellowship funding will allow a recent PhD graduates to boost their research career and enhance their ability to attract and secure future funding. ...

Diabetes and heart disease

Diabetes and heart disease

Diabetes and heart disease

Diabetes is an ongoing health condition where your body’s usual ways of controlling your blood sugar, or blood glucose levels, don’t work properly. ...

What is atrial fibrillation?

What is atrial fibrillation?

What is atrial fibrillation?

Atrial fibrillation is a type of arrhythmia where your heart beats irregularly and fast....

Clinical resources: Coronary heart disease and mental health

Clinical resources: Coronary heart disease and mental health

The prevalence of depression is high in patients with coronary heart disease (CHD)....

Benefits of physical activity for your heart

Benefits of physical activity for your heart

Benefits of physical activity for your heart

Physical activity and exercise can do wonders for your physical and mental health....

Kids recipes

Kids recipes

Kids recipes

Find heart healthy kids recipes...

Physical activity in the workplace

Physical activity in the workplace

Physical activity in the workplace

Resources to help you create a more physically active workplace....

Women and heart disease

Women and heart disease

Women and heart disease

Information and resources for healthcare professionals....

Key Statistics: Heart Failure

Key Statistics: Heart Failure

Statistics and information on heart failure in Australia ...

COVID-19 info & FAQs

COVID-19 info & FAQs

COVID-19 info & FAQs

Information and FAQs about COVID-19 and heart disease....

Aboriginal heart health

Aboriginal heart health

Aboriginal heart health

Visit the St Vincents Hospital NSW and Heart Foundation Aboriginal heart health website for more information...

Lipid management clinical information and resources

Lipid management clinical information and resources

Lipid management resources for health professionals...

Grilled haloumi and crunchy green salad

Grilled haloumi and crunchy green salad

Grilled haloumi and crunchy green salad

8-10 minutes
Serves 4 (as a side)

What is a heart attack?

What is a heart attack?

What is a heart attack?

The most common cause of a heart attack is coronary heart disease....