Show me:
Show me:
A universal framework to quantify rotor formation and destruction in atrial fibrillation
heartfoundation.org.au|Helpline 13 11 12

A universal framework to quantify rotor formation and destruction in atrial fibrillation

Associate Professor Anand Ganesan, Institution: Flinders University

2019 Vanguard Grant

Years funded: 2020-2021


Atrial fibrillation (AF) is the most common cardiac arrhythmia, and the leading cause of cardiac hospitalisation in Australia. For over 100 years, it has been recognised that a key feature of cardiac fibrillation is the presence of unstable functional re-entrant circuits known as rotors, which have been postulated as the drivers of AF. Rotors are like mini vortices of electricity that perpetually form and annihilate during both forms of cardiac fibrillation. In NHMRC Project grant (1063754, CIA Ganesan) and NHF FLF (101188, CIA Ganesan) we developed a universal renewal-theory based quantitative framework to measure for the first time the rates at which rotors form and die during fibrillation.

We validated this approach in 6 systems including human and experimental AF and VF. Here, we conduct an integrated bench-to-bedside investigation of renewal processes of rotor formation and destruction using computational simulation, experimental models and human studies.

The application will determine:
  1. The ion channel and substrate determinants of these rate constants, and their association with AF termination in pre-clinical computational and experimental studies;
  2. The clinical correlates of the rate constants of rotor formation and destruction in human AF patients undergoing ablation, with the long-term objective of developing the rate constants of rotor formation and destruction as a new marker of AF prognosis, and potential targets for therapeutic modulation.

The team combines cross-disciplinary technical expertise in clinical and experimental arrhythmia science, along with mathematics. The project will deliver not only fundamental new mechanistic knowledge of profound interest to basic arrhythmia research but defines the properties of a powerful new paradigm that has the potential to transform the clinical care of atrial fibrillation patients.

You might also be interested in

Research Directory

Research Directory

A program of research to improve ACCESS to cardiovascular care

A program of research to improve ACCESS to cardiovascular care

Professor Robyn Clark, Institution: Flinders University...

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Assistant Professor Neil Spratt, Institution: The University of Newcastle...

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Ms Joanne Luke, Institution: University of Melbourne...

Exercise and brain volume loss after stroke

Exercise and brain volume loss after stroke

Professor Amy Brodtmann, Institution: Florey Institute of Neuroscience and Mental Health...

Growing healthy hearts - how passive smoke exposure and elevated blood pressure early in life impacts adult cardiovascular health

Growing healthy hearts - how passive smoke exposure and elevated blood pressure early in life impacts adult cardiovascular health

Growing healthy hearts - how passive smoke exposure and elevated blood pressure early in life impacts adult cardiovascular health

Dr Costan Magnussen, Institution: University of Tasmania...

Lipid disorders in patients at high cardiovascular disease risk

Lipid disorders in patients at high cardiovascular disease risk

Dr Esther Ooi, Institution: University of Western Australia...

Promoting active, healthy lifestyles among women at key life stages

Promoting active, healthy lifestyles among women at key life stages

Associate Professor Verity Cleland, Institution: University of Tasmania...

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Professor Bruce Neal, Institution: University of New South Wales...

Starting early – Increasing young children’s physical activity

Starting early – Increasing young children’s physical activity

Associate Professor Hayley Christian, Institution: University of Western Australia...

Heart Health Check Toolkit

Heart Health Check Toolkit

Health Professional Tools

Health Professional Tools

Health Professional Tools

Guidelines, publications and support for the health professional community....

Heart Week 2022

Heart Week 2022

Heart Week 2022

With one Australian having a heart attack or stroke every 4 minutes, you have the power to change this statistic. ...

Together, we can change the future of heart disease

Together, we can change the future of heart disease

Together, we can change the future of heart disease

The power of your ongoing support can help save lives and keep more families together. Help us continue to fund promising heart research projects by donating today. ...

Time to book a Heart Health Check?

Time to book a Heart Health Check?

Time to book a Heart Health Check?

If you're 45 and over, or 30 and over if you're of Aboriginal or Torres Strait Islander descent, you should book your Heart Health Check today...

WEBINAR | Pressure rising: Clinical controversies and updates in hypertension

WEBINAR | Pressure rising: Clinical controversies and updates in hypertension

WEBINAR | Pressure rising: Clinical controversies and updates in hypertension

Our Annual Reports

Our Annual Reports

Our Annual Reports

Discover our Annual reports from 2013 onwards. ...

Confidential. Personal. Reliable.

Confidential. Personal. Reliable.

Confidential. Personal. Reliable.

Got a question about your heart?...

Snack recipes

Snack recipes

Snack recipes

Search for healthy snack ideas...

Chicken recipes

Chicken recipes

Chicken recipes

Find heart healthy chicken recipes....

Your heart medicines

Your heart medicines

Your heart medicines

Information about commonly prescribed heart medicines. ...

Heart disease and pregnancy

Heart disease and pregnancy

Heart disease and pregnancy

Pregnancy is often referred to as the “ultimate stress test” for the body....

Vegetarian recipes

Vegetarian recipes

Vegetarian recipes

Search through our vegetarian recipes...

How to implement improved care of familial hypercholesterolaemia in Australia

How to implement improved care of familial hypercholesterolaemia in Australia

Dr Mitchell Sarkies, Institution: Macquarie University...

9 food and heart health myths, busted

9 food and heart health myths, busted

9 food and heart health myths, busted

Let’s dive into nine common food and health myths and the facts behind them....

Longitudinal Impact of CT-defined leaflet thrombosis after transcatheter aortic valve replacement

Longitudinal Impact of CT-defined leaflet thrombosis after transcatheter aortic valve replacement

Dr Hashrul Rashid, Institution: Monash University...

Enhancing Cardiovascular Risk Prediction in Patients undergoing Liver Transplantation

Enhancing Cardiovascular Risk Prediction in Patients undergoing Liver Transplantation

Dr Anoop Koshy, Institution: The University of Melbourne...

For professionals: Cardiovascular disease risk assessment for Aboriginal and Torres Strait Islander peoples 

For professionals: Cardiovascular disease risk assessment for Aboriginal and Torres Strait Islander peoples 

Recommendations for assessing Cardiovascular disease (CVD) risk in Aboriginal and Torres Strait Islander peoples ...

Italian veggie fritters with tomato salad

Italian veggie fritters with tomato salad

Italian veggie fritters with tomato salad

20 minutes
Serves 4 (as a main meal)

Research Directory

Research Directory

Relationships and sex after a heart attack

Relationships and sex after a heart attack

Relationships and sex after a heart attack

Explore some useful things to know about intimacy after a heart attack....

Chest x-ray for heart disease

Chest x-ray for heart disease

Chest x-ray for heart disease

This test can help your doctor determine if there is anything wrong with your heart....

COVID-19 info & FAQs

COVID-19 info & FAQs

COVID-19 info & FAQs

Information and FAQs about COVID-19 and heart disease....

Absolute CVD risk assessment resources

Absolute CVD risk assessment resources

Resources and clinical information for health professionals...

For Professionals: Coronary artery calcium scoring

For Professionals: Coronary artery calcium scoring

The National Heart Foundation of Australia Position Statement: Coronary artery calcium scoring for the primary prevention of cardiovascular disease in Australia.¹...

Exercises to do at home

Exercises to do at home

Exercises to do at home

All you need to know about keeping active during COVID-19....

Chicken and avocado banh mi

Chicken and avocado banh mi

Chicken and avocado banh mi

15 minutes + 30 minutes chilling
Serves 4

$2 million for cardiovascular research targeting diet, physical activity and mental health

$2 million for cardiovascular research targeting diet, physical activity and mental health

$2 million for cardiovascular research targeting diet, physical activity and mental health

Media Release - 23 June 2021...

Aboriginal and Torres Strait Islander peoples: Heart Health Projects

Aboriginal and Torres Strait Islander peoples: Heart Health Projects

Aboriginal and Torres Strait Islander peoples: Heart Health Projects

Projects aimed at improving the heart health of Aboriginal and Torres Strait Islander peoples ...

Chicken caprese pizza

Chicken caprese pizza

Chicken caprese pizza

20 minutes
Serves 2 (1 pizza per serve)