Show me:
Show me:
heartfoundation.org.au|Helpline 13 11 12

A new therapy to protect our brain and kidneys during heart surgery requiring the heart-lung machine

Dr Yugeesh Lankadeva, Institution: Florey Institute of Neuroscience and Mental Health

2020 Vanguard Grant

Years funded: 2021-2022


Every year over 20,000 Australians have surgical operations to repair their damaged hearts that require the use of a heart-lung bypass machine. However, a major unresolved complication of heart-lung bypass surgery is that there is injury to the brain in about 50% of patients and there is injury to the kidneys in about 30% of patients. The development of post-operative brain and kidney injuries increases the length of hospital stay and the risk of in-hospital death and can in the long-term substantially diminish a patient’s quality of life. There are currently no effective therapies to prevent or reverse brain and kidney injuries after heart-lung bypass surgery.

A major barrier to the development of interventions to prevent brain and kidney injuries has been the lack of a clinically relevant animal model in which the entire patient experience, before, during and after heart-lung bypass surgery can be simulated for trialling new therapies. We have recently developed a clinically relevant large animal model in which we can continuously monitor blood perfusion and the amount of oxygen in the tissue of the brain and kidneys before, during the entire course of heart-lung bypass surgery and then during recovery from this operation. The aim of this project is to understand the pathological changes that occur within the brain and kidneys during heart-lung bypass surgery and to re-purpose a pre-existing clinically approved drug to reverse these detrimental effects. This would represent a true breakthrough in our ability to prevent post-operative brain and kidney injury, and greatly improve the health outcomes for these patients that currently lack any effective therapies.

You might also be interested in

Research Directory

Research Directory

A program of research to improve ACCESS to cardiovascular care

A program of research to improve ACCESS to cardiovascular care

Professor Robyn Clark, Institution: Flinders University...

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Altering the rehabilitation environment to improve stroke survivor activity (AREISSA)

Assistant Professor Neil Spratt, Institution: The University of Newcastle...

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Constructing Aboriginal health: a review of cardiovascular research, 1933-2014

Ms Joanne Luke, Institution: University of Melbourne...

Exercise and brain volume loss after stroke

Exercise and brain volume loss after stroke

Professor Amy Brodtmann, Institution: Florey Institute of Neuroscience and Mental Health...

Growing healthy hearts - how passive smoke exposure and elevated blood pressure early in life impacts adult cardiovascular health

Growing healthy hearts - how passive smoke exposure and elevated blood pressure early in life impacts adult cardiovascular health

Growing healthy hearts - how passive smoke exposure and elevated blood pressure early in life impacts adult cardiovascular health

Dr Costan Magnussen, Institution: University of Tasmania...

Lipid disorders in patients at high cardiovascular disease risk

Lipid disorders in patients at high cardiovascular disease risk

Dr Esther Ooi, Institution: University of Western Australia...

Promoting active, healthy lifestyles among women at key life stages

Promoting active, healthy lifestyles among women at key life stages

Associate Professor Verity Cleland, Institution: University of Tasmania...

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Reducing population salt consumption in Victoria

Professor Bruce Neal, Institution: University of New South Wales...

Starting early – Increasing young children’s physical activity

Starting early – Increasing young children’s physical activity

Associate Professor Hayley Christian, Institution: University of Western Australia...

Health Professional Tools

Health Professional Tools

Health Professional Tools

Guidelines, publications and support for the health professional community....

Together, we can change the future of heart disease

Together, we can change the future of heart disease

Together, we can change the future of heart disease

The power of your ongoing support can help save lives and keep more families together. Help us continue to fund promising heart research projects by donating today. ...

Time to book a Heart Health Check?

Time to book a Heart Health Check?

Time to book a Heart Health Check?

If you're 45 and over, or 30 and over if you're of Aboriginal or Torres Strait Islander descent, you should book your Heart Health Check today...

Heart Health Check Toolkit

Heart Health Check Toolkit

Key Statistics: Heart Failure

Key Statistics: Heart Failure

Statistics and information on heart failure in Australia ...

Automated Implantable Cardioverter Defibrillator (ICD or AICD)

Automated Implantable Cardioverter Defibrillator (ICD or AICD)

This is a device inserted into your chest to return abnormal heart rhythms to normal using electrical impulses. ...

Sit less, move more

Sit less, move more

Sit less, move more

You may be surprised to know that on average, adults sit for nine hours a day....

Heart attack recovery – quit smoking

Heart attack recovery – quit smoking

Heart attack recovery – quit smoking

Smoking is a major risk factor for heart disease. Get the facts on quitting and how it can help you recover. ...

Mexican spice blend

Mexican spice blend

Mexican spice blend

5 minutes

A new way to regulate blood and liver fats

A new way to regulate blood and liver fats

Associate Professor Anna Calkin, Institution: Baker Heart and Diabetes Institute...

What is an arrhythmia?

What is an arrhythmia?

What is an arrhythmia?

Arrhythmia is a fault in the heart’s electrical system, which affects your heart’s pumping rhythm....

What is a cardiac arrest?

What is a cardiac arrest?

What is a cardiac arrest?

With immediate help a cardiac arrest can be survived. Learn how to save a life....

Paprika chicken with pumpkin and spinach salad

Paprika chicken with pumpkin and spinach salad

32 minutes
Serves 4

Banana chia pots with mango & passionfruit

Banana chia pots with mango & passionfruit

Banana chia pots with mango & passionfruit

20 minutes + standing & overnight chilling
Serves 2

Matilda signs up for Jump Rope just one month after open-heart surgery

Matilda signs up for Jump Rope just one month after open-heart surgery

Matilda signs up for Jump Rope just one month after open-heart surgery

Media Release - 26 June 2020...

Hot oats – (base recipe)

Hot oats – (base recipe)

Hot oats – (base recipe)

10 minutes
Serves 2

Driving and travelling after a heart attack

Driving and travelling after a heart attack

Driving and travelling after a heart attack

Explore our guide for driving and heart attack recovery. ...

Building digital health trust to improve cardiovascular disease prevention in chronic kidney disease

Building digital health trust to improve cardiovascular disease prevention in chronic kidney disease

Dr Jaimon Kelly, Institution: The University of Queensland...

Salmon Tikka Parcels with Rice Salad

Salmon Tikka Parcels with Rice Salad

Salmon Tikka Parcels with Rice Salad

15 minutes
Serves 4

Physical activity after a heart attack

Physical activity after a heart attack

Physical activity after a heart attack

Discover what you need to know about being active after a heart attack....

Donate Monthly | Become a Regular Donor

Donate Monthly | Become a Regular Donor

Donate Monthly | Become a Regular Donor

Join the fight against heart disease....

Lunch recipes

Lunch recipes

Lunch recipes

Search our lunch recipe ideas...

Cellular-resolution imaging catheter to reliably identify individuals at high-risk of heart attacks

Cellular-resolution imaging catheter to reliably identify individuals at high-risk of heart attacks

Dr Li Jiawen, Institution: University of Adelaide...

Nutrition after a heart attack

Nutrition after a heart attack

Nutrition after a heart attack

Discover key information on heart-healthy eating and drinking....

Italian fish parcels

Italian fish parcels

Italian fish parcels

20 minutes
Serves 2

National Stroke Data Linkage Program: Using data to improve stroke monitoring, care and outcomes

National Stroke Data Linkage Program: Using data to improve stroke monitoring, care and outcomes

Associate Professor Monique Kilkenny, Institution: Monash University...

Patient-derived arteries in a box

Patient-derived arteries in a box

Associate Professor Steven Wise, Institution: University of Sydney...

Heart disease and pregnancy

Heart disease and pregnancy

Heart disease and pregnancy

Pregnancy is often referred to as the “ultimate stress test” for the body....

E O Myers Trust Fund

E O Myers Trust Fund

The E O Myers Trust Fund provides grants to support medical education, advancing the knowledge and skill of cardiology health professionals in South Australia....

Prawn and avocado salad

Prawn and avocado salad

20 minutes
Serves 6